Cancer Immunology

Faculty with interest in cancer immunology are on the leading edge of research in tumor antigen discovery, antigen presentation with special emphases on dendritic cells, lymphocyte specificity and activation, cytokine action, and in vivo vaccination strategies to develop safe and effective treatments for cancer by enhancing anti-cancer immune responses. Related studies in this area include the search for underlying genetic or biochemical defects that lead to cell transformation and tumorigenesis, which also may influence tumor immunogenicity. These studies emphasize intracellular signal transduction, programmed cell death, and oncogene funcation. Other faculty members are studying the development, induction, and regulation of natural killer cell funcation, research that has had a long tradition of excellence at the University of Pittsburgh.