Cell Biology and Molecular Physiology

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The Cell Biology and Molecular Physiology (CBMP) graduate program is made up of a dynamic group of investigators and students who use the modern-day tools of biochemistry, genetics, imaging, and molecular biology to understand the integrated biology and physiology of cells, organs, and whole animals. The faculty is drawn from both basic science and clinical departments and their research is focused on normal cellular biology and function, as well as understanding renal and heart disease, cancer and diabetes, as well as inherited disorders of developmental and reproductive functions. Further information about our program can be found at the Cell Biology And Molecular Physiology homepage.

Research

CBMP students interact and work with an internationally recognized faculty, whose research is supported by grants from the National Institutes of Health and from other national research granting organizations. Faculty research includes study of normal cell biology and function, as well as a broad range of diseases that have a cell biological basis. Examples of their research interests include:

  • Cell Communication and Imaging
  • Cellular Injury and Wound Healing Chromatin, DNA Repair, Cell-Cyle Control, and Gene Expression
  • Ion Channel Biology
  • Membrane Traffic of Proteins and Lipids
  • Signal Transduction in Diabetes and Metabolism

Faculty

Gerard L. Apodaca
Professor
Regulation of endocytic traffic by the exocyst complex; stretch-regulated exocytosis/endocytosis in bladder umbrella cells
Meir Aridor
Associate Professor
The molecular basis for COP II mediated cargo selection, export, transport to the Golgi. The regulation of cargo degradation in the ER. Biogenesis of CFTR in the early secretory pathway. Biosynthetic transport mechanisms in primary neurons.
Jeffrey L Brodsky
Protein biogenesis and degradation
Michael Bruce Butterworth
Assistant Professor
Renal microRNAs (miR) linked to regulation of epithelial ion transport. Hormonal control of miR expression. Role of miR targets in sodium homeostasis.
Marcelo Daniel Carattino
Assistant Professor
epithelial ion transport, and regulation of ion channels by mechanical forces
Daniel C. Devor
Professor
Structure-function studies on the trafficking, assembly, and regulation of calcium-dependent potassium channels
Peter F. Drain
Associate Professor
Understanding insulin secretion, dopamine secretion, and structure-mechanism relations underlying the ATP-inhibited potassium (KATP) channel response to physiologically important ligands, in degenerative diseases
Marijn Ford
Raymond A. Frizzell
Professor
Epithelial ion transport and cell biology; the molecular mechanisms responsible for defects in epithelial electrolyte secretion and absorption in cystic fibrosis and renal disease.
James L. Funderburgh
Professor
Roles for extracellular matrix in cellular responses during wound healing and tissue regeneration; Properties and bioengineering applications of adult stem cells in the eye
Arjumand Ghazi
Assistant Professor
Molecular genetics of aging in C. elegans; Lab Webpage: http://www.chp.edu/CHP/ghazilab
Eric Goetzman
Gerald Hammond
Yang Hong
Associate Professor
Epithelial polarity and tumorigenesis in Drosophila and mammalian cells.
Rebecca P. Hughey
Professor
Assembly and proteolytic activation of the epithelial sodium channel
Ossama Kashlan
Thomas R. Kleyman
Professor
Structure, function, and regulation of epithelial sodium channels; epithelial potassium channels
Adam Vincent Kwiatkowski
Assistant Professor
Organization and dynamics of actin networks
Samuel Lamitina
We use the nematode C. elegans to investigate the mechanisms underlying age-related neurodegenerative diseases like ALS.
Sanford H Leuba
Associate Professor
chromatin structure and dynamics is of major importance in regulating transcription, replication and repair; single molecule approaches to dynamic protein/nucleic acid interactions
Rama K Mallampalli
Professor
mammalian phospholipid metabolism in models of inflammatory lung injury
Sandra A. Murray
Professor
Molecular mechanisms regulating gap junction protein trafficking; the role of signal transduction and cell-cell communication in the regulation of cell proliferation, transformation,secretion, motility, and endocrine response
Matthew L Nicotra
Assistant Professor
Aleksander Rajkovic
Associate Professor
Whole genome sequencing in reproductive pathology, genome editing to model human variants, transcriptional control of oocyte differentiation.
Partha Roy
The two main research interests of our lab are cancer biology (specifically cancer metastasis) and angiogenesis.
Guy Salama
Professor
Elucidating the mechanisms responsible for the initiation and termination of cardiac arrythmias
Gerald Phillip Schatten
Professor
Molecular basis of reproduction and development; Stem cells and transplantation
Sunder Sims-Lucas
Alexander Davidovich Sorkin
Professor
to understand how endocytosis and post-endocytic trafficking regulates function(s) of the transmembrane proteins, such as receptors and transporters
Claudette M. St. Croix
physiological role of nitric oxide (NO)-zinc mediated cell signaling on endothelial function
Donna B. Stolz
Associate Professor
Signal transduction pathways that regulate normal neovascularization in the regenerating of the liver
Arohan R Subramanya
Assistant Professor
Regulation of thiazide-sensitive NaCl contransport, blood pressure and potassium homeostasis
Shivalingappa Kottur Swamynathan
Assistant Professor
regulation of gene expression during ocular surface development and maintenance
Agnieszka Swiatecka-Urban
Assistant Professor
intracellular protein trafficking in human epithelial cells; specific focus on CFTR and nephrin
Patrick Harlan Thibodeau
Assistant Professor
Structure function relationships in membrane proteins; regulation of membrane protein biogenesis, recycling and degradation
Stephen Howard Thorne
Assistant Professor
Linton M. Traub
Associate Professor
We study molecules and mechanisms of receptor-mediated endocytosis using a variety of approaches, ranging from structural biology to animal models.
William H. Walker
Associate Professor
Defining how the Sertoli cells translate hormone stimuli into alterations in gene expression that are required for male reproduction.
Yong Wan
Associate Professor
The role of ubiquitin-dependent proteolysis in biological regulation; the control of cell cycle progression by proteolytic regulation.
Simon C. Watkins
Professor
Development, assembly and integration of the dystrophin cytoskeleton and its potential role(s) in establishing and maintaining normal muscle function
Ora A. Weisz
Professor
Apical membrane targeting mechanisms in polarized epithelial cells
David C. Whitcomb
Professor
Genetics of acute and chronic pancreatitis and genetics of pancreatic cancer; Neurohormonal control of pancreatic exocrine secretion and pathophysiologic processes including the effects of alcohol and genetic predisposition; pancreatic physiology
Judith L Yanowitz
Assistant Professor
Chromatin structure and dynamics during gamete formation and DNA damage repair