Gerard L. Apodaca
Regulation of endocytic traffic by the exocyst complex; stretch-regulated exocytosis/endocytosis in bladder umbrella cells
The molecular basis for COP II mediated cargo selection, export, transport to the Golgi. The regulation of cargo degradation in the ER. Biogenesis of CFTR in the early secretory pathway. Biosynthetic transport mechanisms in primary neurons.
Jeffrey L Brodsky
Protein biogenesis and degradation
Michael Bruce Butterworth
Renal microRNAs (miR) linked to regulation of epithelial ion transport. Hormonal control of miR expression. Role of miR targets in sodium homeostasis.
Marcelo Daniel Carattino
epithelial ion transport, and regulation of ion channels by mechanical forces
Daniel C. Devor
Structure-function studies on the trafficking, assembly, and regulation of calcium-dependent potassium channels
Peter F. Drain
Understanding insulin secretion, dopamine secretion, and structure-mechanism relations underlying the ATP-inhibited potassium (KATP) channel response to physiologically important ligands, in degenerative diseases
Raymond A. Frizzell
Epithelial ion transport and cell biology; the molecular mechanisms responsible for defects in epithelial electrolyte secretion and absorption in cystic fibrosis and renal disease.
James L. Funderburgh
Roles for extracellular matrix in cellular responses during wound healing and tissue regeneration; Properties and bioengineering applications of adult stem cells in the eye
Molecular genetics of aging in C. elegans; Lab Webpage: http://www.chp.edu/CHP/ghazilab
Epithelial polarity and tumorigenesis in Drosophila and mammalian cells.
Rebecca P. Hughey
Assembly and proteolytic activation of the epithelial sodium channel
Thomas R. Kleyman
Structure, function, and regulation of epithelial sodium channels; epithelial potassium channels
Adam Vincent Kwiatkowski
Organization and dynamics of actin networks
We use the nematode C. elegans to investigate the mechanisms underlying age-related neurodegenerative diseases like ALS.
Sanford H Leuba
chromatin structure and dynamics is of major importance in regulating transcription, replication and repair; single molecule approaches to dynamic protein/nucleic acid interactions
Rama K Mallampalli
mammalian phospholipid metabolism in models of inflammatory lung injury
Sandra A. Murray
Molecular mechanisms regulating gap junction protein trafficking; the role of signal transduction and cell-cell communication in the regulation of cell proliferation, transformation,secretion, motility, and endocrine response
Matthew L Nicotra
Whole genome sequencing in reproductive pathology, genome editing to model human variants, transcriptional control of oocyte differentiation.
The two main research interests of our lab are cancer biology (specifically cancer metastasis) and angiogenesis.
Elucidating the mechanisms responsible for the initiation and termination of cardiac arrythmias
Gerald Phillip Schatten
Molecular basis of reproduction and development; Stem cells and transplantation
Alexander Davidovich Sorkin
to understand how endocytosis and post-endocytic trafficking regulates function(s) of the transmembrane proteins, such as receptors and transporters
Claudette M. St. Croix
physiological role of nitric oxide (NO)-zinc mediated cell signaling on endothelial function
Donna B. Stolz
Signal transduction pathways that regulate normal neovascularization in the regenerating of the liver
Arohan R Subramanya
Regulation of thiazide-sensitive NaCl contransport, blood pressure and potassium homeostasis
Shivalingappa Kottur Swamynathan
regulation of gene expression during ocular surface development and maintenance
intracellular protein trafficking in human epithelial cells; specific focus on CFTR and nephrin
Patrick Harlan Thibodeau
Structure function relationships in membrane proteins; regulation of membrane protein biogenesis, recycling and degradation
Stephen Howard Thorne
Linton M. Traub
We study molecules and mechanisms of receptor-mediated endocytosis using a variety of approaches, ranging from structural biology to animal models.
William H. Walker
Defining how the Sertoli cells translate hormone stimuli into alterations in gene expression that are required for male reproduction.
The role of ubiquitin-dependent proteolysis in biological regulation; the control of cell cycle progression by proteolytic regulation.
Simon C. Watkins
Development, assembly and integration of the dystrophin cytoskeleton and its potential role(s) in establishing and maintaining normal muscle function
Ora A. Weisz
Apical membrane targeting mechanisms in polarized epithelial cells
David C. Whitcomb
Genetics of acute and chronic pancreatitis and genetics of pancreatic cancer; Neurohormonal control of pancreatic exocrine secretion and pathophysiologic processes including the effects of alcohol and genetic predisposition; pancreatic physiology
Judith L Yanowitz
Chromatin structure and dynamics during gamete formation and DNA damage repair